The smart Trick of ceesdekker That Nobody is Discussing
The smart Trick of ceesdekker That Nobody is Discussing
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Rotary movement of DNA rotors on nanopores. Prime row: raw movie in the Cy5 channel of each and every rotor. Middle row: corresponding one-particle localization final results of both finishes of the DNA rotors. The situation of the present body is marked as orange and blue dots, as well as the trajectory of the 10 frames just before The existing body is proven as solid strains.
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Multicolor imaging with the bacterial nucleoid and cell division proteins with blue, orange, and close to-infrared fluorescent proteins
A rhythmically pulsing leaf-spring DNA-origami nanoengine that drives a passive follower Mathias Centola
2012, discovery that nucleoid occlusion underlies the precision of bacterial cell division; and to start with ever analyze on the dynamics DNA supercoils and the discovery of supercoil hopping
The coiled-coil with the human Rad50 DNA mend protein is made up of precise segments of enhanced flexibility
Because 2000 he moved to single-molecule biophysics and nanobiology, with investigate from DNA supercoiling scientific tests of nucleosomes and DNA mend proteins to DNA translocation by means of nanopores. Lately his research has centered on learning mobile division with micro organism on chip, although his ultimate desire is inside the direction of knowing synthetic cells.
Move-pushed rotary motors like windmills and water wheels generate useful procedures in human Culture. Whilst samples of such rotary motors also function prominently in mobile biology, their artificial development for the nanoscale has remained complicated. Here we https://www.ceesdekker.net demonstrate movement-driven rotary motion of a self-organized DNA nanostructure that is docked onto a nanopore in a thin solid-state membrane. An elastic DNA bundle self-assembles right into a chiral conformation on phoretic docking on to the stable-point out nanopore, and subsequently shows a sustained unidirectional rotary movement of up to 20 rev s−1.
The rotors harness energy from the nanoscale water and ion stream that is certainly generated by a static chemical or electrochemical opportunity gradient while in the nanopore, which can be established by way of a salt gradient or applied voltage, respectively. These synthetic nanoengines self-organize and work autonomously in physiological situations, suggesting approaches to developing Strength-transducing motors at nanoscale interfaces.
It was in the course of this period that Dekker completed exploration on magnetic spin units and on noise in superconductors and semiconductors.
Screening pseudotopological and nontopological models for SMC-driven DNA loop extrusion from roadblock-traversal experiments
Character Physics thanks the nameless reviewers for their contribution to your peer overview of this get the job done.
For example, we think about the nucleopore intricate, a gateway among the cell nucleus plus the cytoplasm. This is an extremely complex system and as a consequence tough to research inside of a cell, so we use biomimetics. We reconstruct holes and after that insert unique aspects from the nucleopore elaborate to review transport by it at the single-molecule amount.’
Dekker heeft fundamentele ontdekkingen gedaan op het gebied van koolstof nanobuisjes. Mede vanwege deze werkzaamheden is hij al jaren de meest geciteerde fysicus in Nederland. Tegenwoordig onderzoekt hij satisfied enkel-molecuultechnieken de biofysica van moleculen in de biologische cel. Dekker is naast zijn wetenschappelijk werk ook bekend vanwege zijn belangstelling voor de relatie tussen geloof en wetenschap en de discussie rond clever style in 2005. (nl)